Our Mission: Better Health Starts From Within

At akkermansia.org, we believe that the secret to a vibrant, high-quality life isn’t found in a quick fix—it’s cultivated in your gut.

Modern life is tough on our microbiomes. Between processed foods, daily stress, and environmental toxins, the delicate balance of our internal ecosystem is under constant attack. When that balance breaks, it doesn’t just stay in the gut. From brain fog and low energy to systemic inflammation and "leaky gut," the health of your microbiome dictates the health of your entire body.

We are here to change that narrative.

After years of searching for the key to gut health, we have reached a monumental turning point. We now know that long-term probiotic cultivation is more than just a supplement—it is the catalyst that accelerates deep healing. This isn't just theory; it’s a breakthrough. In the field of cancer research, the presence of Akkermansia is proving to be the missing piece of the puzzle, potentially making the definitive difference in the journey toward a cure.

Scientific Bibliography: Akkermansia muciniphila

Foundational Human & Metabolic Research

  • Depommier, C., et al. (2019). Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nature Medicine, 25, 1096–1103. https://doi.org/10.1038/s41591-019-0495-2

  • Yoon, H. S., et al. (2021). Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis. Nature Microbiology, 6(5), 563-573. https://doi.org/10.1038/s41564-021-00880-5

  • Zhang, L., et al. (2025). Live vs. Pasteurized Akkermansia: A comparative clinical analysis of gut barrier restoration and tight-junction protein expression. Frontiers in Microbiology, 16, 1142–1155.

Oncology & Immunotherapy Synergies

  • Routy, B., et al. (2018). Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors. Science, 359(6371), 91-97. https://doi.org/10.1126/science.aan3706

  • Derosa, L., et al. (2022). Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer. Nature Medicine, 28, 315–324. https://doi.org/10.1038/s41591-021-01655-5

  • Jiang, Y., et al. (2025). Akkermansia muciniphila reprograms immunosuppressive microenvironment via efferocytosis inhibition to sensitize anti-PD-1 therapy in MSS colorectal cancer: A Phase I trial. Journal for ImmunoTherapy of Cancer, 13(Suppl 2).

  • Wu, X., et al. (2025). Intestinal Akkermansia muciniphila complements the efficacy of PD1 therapy in MAFLD-related hepatocellular carcinoma. Cell Reports Medicine, 6(1), 101-118.

Dietary Interventions & Prebiotics

  • Anhe, F. F., et al. (2015). A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population. Gut, 64(6), 872-883. https://doi.org/10.1136/gutjnl-2014-307142

  • Roopchand, D. E., et al. (2015). Dietary Polyphenols Promote Growth of the Gut Bacterium Akkermansia muciniphila and Attenuate High-Fat Diet–Induced Metabolic Syndrome. Diabetes, 64(8), 2835-2846. https://doi.org/10.2337/db14-1916

  • Régnier, M., et al. (2020). Rhubarb Supplementation Prevents Diet-Induced Obesity and Diabetes in Association with Increased Akkermansia muciniphila in Mice. Nutrients, 12(10), 2947. https://doi.org/10.3390/nu12102947

  • Jantz, K., & Milazzo, N. (2025). Clinical review: Can dietary interventions and calorie restriction increase Akkermansia muciniphila abundance in humans? Examine Research Review, Updated May 2025.

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